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KMID : 0923620210210060038
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Immune Network
2021 Volume.21 No. 6 p.38 ~ p.38
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SARS-CoV-2 Omicron Mutation Is Faster than the Chase: Multiple Mutations on Spike/ACE2 Interaction Residues
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Kim Si-Nae
Nguyen Tam T.
Taitt Afeisha S.
Jhun Hyun-Jhung
Park Ho-Young
Kim Sung-Han
Kim Yong-Gil
Song Eun-Young
Lee Young-Min
Yum Ho-Kee
Shin Kyeong-Cheol
Choi Yang-Kyu
Song Chang-Seon
Yeom Su-Cheong
Kim Byoung-Guk
Netea Mihai
Kim Soo-Hyun
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Abstract
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Recently, a new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (B.1.1.529) Omicron variant originated from South Africa in the middle of November 2021. SARS-CoV-2 is also called coronavirus disease 2019 (COVID-19) since SARS-CoV-2 is the causative agent of COVID-19. Several studies already suggested that the SARS-CoV-2 Omicron variant would be the fastest transmissible variant compared to the previous 10 SARS-CoV-2 variants of concern, interest, and alert. Few clinical studies reported the high transmissibility of the Omicron variant but there is insufficient time to perform actual experiments to prove it, since the spread is so fast. We analyzed the SARS-CoV-2 Omicron variant, which revealed a very high rate of mutation at amino acid residues that interact with angiostatin-converting enzyme 2. The mutation rate of COVID-19 is faster than what we prepared vaccine program, antibody therapy, lockdown, and quarantine against COVID-19 so far. Thus, it is necessary to find better strategies to overcome the current crisis of COVID-19 pandemic.
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KEYWORD
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COVID-19 Omicron, SARS-CoV-2, Spike (S) gene, Mutation, Receptor binding motif (RBM)
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